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Platinum-based drugs are the first class of metal-based drugs to be clinically used as anticancer agents following the approval of cisplatin by the United States Food and Drug Administration (FDA) over 40 years ago

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difference: 6.8%, P = 0.17), but brain atrophy rates and cognitive decline showed no significant differences (Tzimopoulou et al., 2010)

Second, the study population was focused on Europeans, so the conclusions cannot be generalized to larger populations for the time being

doi: 10.1158/1078-0432.CCR-23-0011 [DOI] [PMC free article] [PubMed] [Google Scholar] 378